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Publication in PNAS: Double-stranded DNA translocase activity of TFIIH and the mechanism of RNAP Polymerase II Open Complex formation.

The essential transcription initiation factor TFIIH translocates along double-stranded DNA. The Ssl2 subunit, previously thought to act as a helicase to convert dsDNA into ssDNA actually walks along dsDNA without unwinding. This explains structural results showing that Ssl2 does not… Read More »Publication in PNAS: Double-stranded DNA translocase activity of TFIIH and the mechanism of RNAP Polymerase II Open Complex formation.