The search for a downstream start site does not depend on transcription by RNAP II. Furthermore, the dsDNA translocase is able to utilize GTP in addition to ATP to drive the scanning mechanism. These observations further constrain models for transcription initiation in S. cerevisiae.
New Publication in JBC: Transcription start site scanning and the requirement for ATP during Transcription Initiation by RNAP II.
- by Eric Galburt